Synthèse d’une nouvelle famille de phosphonates bioactives, étude structurale et mise en évidence d’aspects pharmacologiques

Abstract

The present study focuses on the synthesis of three new α-aminophosphonate molecules: 5-HMAP, 5-HNAP and 4-HNAP, obtained according to the three-component reaction of Kabachnik Fields. The structure of the molecules synthesized was characterized by physicochemical and spectroscopic methods: R-X, NMR, FT-IR and UV-Vis. The synthesized molecules have been subjected to extensive laboratory-scale experiments to determine their biopharmaceutical activity as antioxidants, anti-Alzheimer's, anti-diabetic, anti-ulcer, anti inflammatory, antimicrobial, anti-hemolytic, and protective power against SPF solar radiation. Molecular modeling is carried out by three methods; The DFT method is performed for the demonstration of chemical reactivity and to establish a correlation between molecular structures and biological activity. The structure-activity relationship QSAR and prediction of the similarity of our compounds to drugs was carried out using specialized software. The empirical study by the molecular docking method was used to estimate the affinity between (AChE, BChE and alpha-amylase). The experimental and theoretical results show that the synthesized molecules possess important biological activities and promising pharmaceutical properties.