Synthèse caractérisation et évaluation de l'activité biologique de la protection contre la corrosion et étude théorique des trois composés base de Schiff

Abstract

This work presents the synthesis and characterisation of new Schiff base compounds DL, PL, and AL using various physico-chemical analysis techniques. The antioxidant, enzymatic, anti-inflammatory, and antimicrobial activities of the synthesized molecules were evaluated. The superoxide radical scavenging test was studied by cyclic voltammetry. The studied compounds were tested to determine their cytotoxicity by the larvae lethality test. The photoprotective efficacy of the synthesized compounds was also determined by measuring the sun protection factor (SPF). On the other hand, the predicted ADME-T and pharmacokinetic parameters indicated that these compounds exhibited good oral bioavailability. The results show that these compounds can be an important source for treating pathological damage without any toxicity. Molecular docking was used to predict the inhibitory activity of the studied ligands on the main protease of 4GCA (Apro). Finally, these compounds were examined as corrosion inhibitors of carbon steel X48 using the gravimetric method. All the experimental results have been confirmed by DFT and SDM