L’intérèt De La Recherche Des Hémolysines Chez Les Donneurs Du Sang Centre de Sang wilaya De Setif (CSW) CHU De Setif

Abstract

Mots-clés : hémolysines ; donneurs du sang, sécurité transfusionnelle, Ac immuns. Abstract: The objective of our study was to investigate immune anti-A and anti-B antibodies among the blood donor population at the Blood Transfusion Center of Sétif, with the aim of improving transfusion safety by establishing a systematic and generalized screening strategy for these antibodies in all blood donors. This retrospective-prospective study was conducted over a period of seven months and included 7,803 donations from blood groups A, B, and O. Hemolysin screening was performed on fresh serum using the tube technique. Among the donations examined, three positive cases of hemolysins were identified (0.053%), including two men (66.66%) and one woman (33.33%). The most affected age group was 20–29 years. Group O accounted for two cases (66.66%), whereas group A accounted for one case (33.33%), with a predominance of Rh-positive donors (100%). Anti-B antibodies were the most frequent (66.66%), followed by anti-A antibodies (33.33%). The screening of anti-A and anti-B hemolysins is mandatory according to Algerian regulations and should be carried out systematically to ensure optimal transfusion safety for all transfusion recipients.