Rôle de l'inflammation dans la lithiase urinaire et potentiel thérapeutique des agents anti-inflammatoires

Abstract

Urinary stones are among the most common conditions in urology, characterized by the formation of solid deposits within the urinary tract. This study aimed to shed light on the relationship between inflammation and stone formation, with a focus on the therapeutic potential of anti-inflammatory agents. A systematic analysis of recent studies was conducted, in addition to reviewing the biological mechanisms responsible for stone formation. The study demonstrated that inflammation directly contributes to creating a favorable environment for crystal formation within the urinary system, thus promoting stone development. Despite the effectiveness of anti-inflammatory drugs in limiting or preventing stone formation, their prolonged and uncontrolled use can have adverse effects on the kidneys and digestive system. As surgical treatments for kidney stones are often expensive and may lead to recurrence, herbal therapies represent a promising alternative due to their safety, effectiveness, cultural acceptance, and limited side effects compared to synthetic medications. The use of plants with both anti-stone and anti-inflammatory properties is encouraged within an integrated preventive and therapeutic approach to urinary stones. The selection of medicinal plants is crucial, both for prevention and treatment. Preferred are those capable of halting the formation of new stones and breaking down existing ones. Diuretic plants are also beneficial, as they can expel deposits