Détermination du taux des oligoéléments sélénium et zinc dans le cheveu des patients atteints par le psoriasis au moyen de la spectrométrie par fluorescence X et de l’activation neutronique instrumentale

Abstract

Selenium and Zinc are essential minerals for the body. They have a positive impact on psoriasis. psoriasis is a multifactorial skin disease with an unknown etiology. The aim of this study is to evaluate the status of selenium and zinc in hair of Algerian psoriatic patients compared to controls of both sexes. Hair samples of psoriatic subjects and controls were collected at the Department of Dermatology at Bab El-Oued Hospital. Two nuclear microanalysis techniques, XRF and INAA, were used. t-test and One-Way ANOVA were applied. Analysis of zinc concentrations in the hair of 42 psoriasis and 24 controls with XRF gave for controls and patients a mean zinc concentrations of 206.35 and 237.48µg/g respectively. These results were validated by the INAA technique. Selenium was not detected by XRF. 58 psoriatic and 31 controls samples were analyzed with INAA. Mean selenium concentrations for controls and patients are 0.39 ± 0.18 mg / g and 0.28 ± 0.13 mg / g respectively. There was a significant difference ( p < 0.05). Selenium concentrations for controls and patients of both sexes are 0.47 ± 0.20µg/g and 0.28 ± 0.10 mg/g for men and 0.35 ± 0.17 mg/g and 0.28 ± 0.14mg/g for women respectively. A significant difference (p0.05). Zinc concentrations in controls and patients for both genders were 171±27 and 151±37 µg/g for men and 145±59 and 178±58 µg/g for women respectively. Mean zinc concentrations for controls and patients were 152±53 and 167±52 µg/g respectively. There is no significant difference (P>0.05). Zinc concentrations in controls and patients for both genders were 171±27 and 151±37 µg/g for men and 145±59 and 178±58 µg/g for women respectively. However, for women, a significant difference …