Fabrication des Nouvelles Préparations à Base de Plantes Médicinales Destinées aux Diabétiques, Personnes Obèses et Sportifs

Abstract

This study focuses on the extraction, characterization, and evaluation of the biological properties of synergistic mixtures of extracts from Curcuma longa, Cinnamomum verum, and Moringa oleifera, highlighting their antioxidant, antibacterial, and toxicological activities. Extraction yields vary according to the composition, with extracts combining turmeric and cinnamon showing the highest yields. The antioxidant activity measured by the DPPH test reveals that the Moringa + Curcuma mixture has the strongest radical-scavenging capacity, although all mixtures are less potent than the standard ascorbic acid, with IC50 values indicating variable effectiveness among the extracts. The antibacterial activity, tested against several Gram-positive and Gram-negative bacterial strains, is moderate, with better action against Bacillus subtilis, especially for the Curcuma + Cinnamon mixture.The toxicological study shows that the ethanolic extract of turmeric and cinnamon, alone or combined with Moringa, presents moderate acute toxicity in rodents, with no mortality at high doses but reversible symptoms. The LD50 is estimated between 921 and 1100 mg/kg, lower than those of the individual extracts, suggesting a synergistic toxic effect. No significant changes in body weight or organ mass were observed in the short term. Biochemical and hematological analyses indicate transient metabolic stress followed by adaptation. Histology reveals reversible kidney damage, while the liver shows cumulative hepatotoxicity with severe lesions at 14 days.These results confirm that despite low acute toxicity, prolonged or high-dose exposure requires particular monitoring, especially of the liver. Overall, the antioxidant and antibacterial efficacy, as well as the toxicological profile of the studied mixtures, support their potential controlled use in therapeutic applications, with caution regarding duration and dosage.