Valeur Pronostique des LDH Plasmatiques dans la COVID-19

Abstract

Coronavirus disease 19 is a global health emergency, responsible for severe forms and high mortality rates. There is an urgent need to explore the prognostic factors of the disease and to identify high-risk cases likely to deteriorate in order to improve management and reduce severity and mortality. Elevated serum lactate dehydrogenase (LDH) levels have been associated with poor outcomes in patients with viral infections. In this context, we conducted a prospective monocentric study including 60 patients with COVID-19, hospitalized or admitted to the intensive care unit at the University Hospital of Bejaia in order t o study the predictive value of LDH and its association with disease severity. After the collection of clinical and biological data of each patient during their stay, statistical analysis were established to study the correlations between serum LDH levels and the factors of disease severity. Mortality and survival rates were also studied in relation to serum LDH levels. The results revealed the presence of a significant correlation between serum LDH levels and the different risk factors (CRP: p=0.017/ N-L: p<0.001/creatinine: p<0.001/ DDimer: p=0.009/ osmolarity: p=0.022/ length of stay in intensive care unit: p=0.03/ mean saturation: p<0.001). In addition, mortality was found to be associated with elevated serum LDH levels. Based on these observations, serum LDH may represent a rapidly measured, effordable biomarker with significant predictive value that may predict patients at the highest risk, allowing them to be prioritized and potentially reducing the mortality rate.