Effets secondaires du paracétamol sur le foie

Abstract

Paracetamol, also known as acetaminophen, is an analgesic and antipyretic drug often used to alleviate headaches and other mild aches and pains. It is an essential component of many cold and flu treatments. In addition, it can be prescribed to manage more severe pain, such as postsurgical pain, and provide palliative care for patients with terminal cancer. Paracetamol is generally safe when used in recommended doses, but excessive use can affect other organs such as the liver, generating oxidative stress that leads to liver toxicity, the main cause of acute liver failure. Paracetamol is mainly metabolized in the liver by two main pathways: In addition, there is a secondary metabolic pathway catalyzed by cytochrome P450 enzymes, which results in the production of a reactive metabolic intermediate known as N-acetyl benzoquinone imine (NAPQI). Under normal conditions of use