Développement de biomatériaux fonctionnels à base de chitosane et d’alginate : Contribution de la réaction de Maillard aux propriétés bioactives.

Abstract

This study explores the formation and bioactivity of Maillard reaction products (MRPs) between chitosan and alginate, focusing on their structural and properties. Chitosan and alginate solutions (1:1, v/v) are heated at 100 °C and pH 4.5 for 3 and 6 hours to form Cs/Alg (3h) and Cs/Alg (6h) MRPs. Structural modifications are confirmed by FTIR, UV-Vis spectroscopy, X-ray diffraction (XRD), analysis (TGA), and zeta potential measurements. The biological properties of both the Synthesized compounds and the initial polymers are assessed, including antioxidant, anti-inflammatory, and antimicrobial activities, with significant observed, particularly after 6 hours of reaction. Blood compatibility and coagulation analysis results suggest their safety for internal use. The MRPs also exhibit significant enzymatic inhibitory activities, particularly against polyphenol oxidase (PPO) and α-amylase, with Cs/Alg (6h) showing the highest α-amylase inhibition. An increase in the sun protection factor (SPF) is also observed.