Étude de la stabilité de la carbamazépine

Abstract

Carbamazepine is a drug in the class of antiepileptic. It is used to treat epilepsy, but also for other conditions such as chronic pain, neuropathic pain, trigeminal neuralgia and some psychiatric mood disorders. Carbamazepine works by modulating the activity of neurotransmitters in the brain, which helps reduce neuronal excitability and relieve the symptoms associated with these conditions. The objective of this study is to assess the stability of carbamazepine, an active substance, in the presence of various excipients used in the formulation of tablets. The study includes the development and validation of an HPLC method for the determination of carbamazepine and for the detection of possible degradation of this active ingredient. The HPLC method uses a C18 column (250*4.6) mm; 5um with a flow rate of 1ml/min, UV detection at 284 nm and a mobile phase consisting of a mixture of (water and methanol) :(40:60 V/V). This developed method is specific, suitability (RSD = 0.24%), linear (R2 = 0.999), exact (recovery = 101.8%), faithful (RSD = 1.1%). Stability study by IR spectrophotometer (IRAffinity-1S FTIR), all formulations showed degradation at 40°C temperature, temperature has no significant effect on the chemical structure of carbamazepine during the study period