Le carbonate de calcium du minerai a la matière première pour usage dans l’industrie pharmaceutique « recherche bibliographique »

Abstract

Calcium carbonate is a mineral compound widely used in nature, found in rocks such as limestone and chalk, as well as in the shells of marine organisms. Due to its unique chemical composition and various physico-chemical properties, calcium carbonate (CaCO3) is used as a raw material in various industrial sectors, including the pharmaceutical industry that consumes large quantities of CaCO3 either as an excipient or as an active ingredient. This work constitutes a bibliographic synthesis on calcium carbonate: its origin, its geographical distribution, including its natural state and its physicochemical properties. A study of its pharmacokinetic properties was also detailed. This thesis also discusses the methods of extraction and manufacture of calcium carbonate. In particular, we will see how the ore is extracted, crushed and purified to obtain the desired shape. While respecting the principles of processing, the industrial processing stage allows us to obtain several finished products with specific characteristics that can be used in a wide range of industrial specialties. In addition to CaCO3 from nature, calcium carbonate can also be obtained by a purely synthetic method, based on chemical reactions. This method is more preferable especially when the product is intended for pharmaceutical or food use and this, for its chemical purity as well as for the control of its synthetic conditions. In order to confirm the composition of calcium carbonate and to guarantee the quality and compliance of this product with the specifications required by industry standards and regulations in force, the finished product must undergo the various purity tests to ensure its safety and suitability for the intended industrial use and to maintain the quality of the final products. In conclusion, this thesis brings together all the information necessary for the elaboration of CaCO3 from the source rock to the finished product; with a view to applying them at national level in order to be able to minimize the import bill of this raw material widely consumed by the various industrial sectors