Synthese et caracterisation de nouveaux derives de la 2-hydroxyquinoxaline et evaluation biologique

Abstract

Molecular compounds with pharmacological activities are the subject of intense studies both experimental at the theoretical level. Research complexes possessing such properties, thus became a strategic issue for the pharmaceutical industry and its therapeutic applications. This work is devoted to the synthesis, evaluation and modeling of new quinoxaliniques derivatives for therapeutic purposes. We present a bibliography on the main pharmacological properties of the quinoxaline nucleus. Subsequently, we were interested in the preparation of new molecules containing this motif by changing the functionality of our substrate. The biological evaluation was carried out by antibacterial and antifungal tests using different bacterial strains. Molecular modeling based on calculations of the minimum energy conformations of the synthesized molecules. The ChemBioOffice 8.0 software has enabled us to resolve ambiguities encountered in the experimental data.