Étude comparative de l'efficacité et des effets secondaires de la carbamazépine versus la lamotrigine chez les patients hospitalises a l'EHS AIN ABASSA

Abstract

The frequency of diagnosis of mood disorders in the world has led to an impressive increase in the prescription of thymoregulatory drugs such as carbamazipine and lamotrigine which are used as antiepileptic but also to treat bipolar disorders with different points in terms of effectiveness and sideeffectsalso the episodetreated mania or depression, this problem has forced us to develop a comparative study on patients at the level of hospital Ain Abassa has the aim of improving the management and therapeutic monitoring of these two molecules It is a retrospective study conducted on a sample of 30 patients under treatment of carbamazepine or LTG; for which we write a questionnaire of 60 questions to fillaccording to the files of the patients We found that Carbamazepine proved to be effective in the treatment of manic and hypomanic episodes and in the prevention of relapses in bipolar rdisorders with a wide therapeutic spectrum, while LTG prevented the recurrence of depressive episodes. Both molecules are prescribed in most cases at low doses. The evolution of psychological state during the treatment is expressed by the follo wing results: 83% of the cases present a good evolution while 17% present an immediate evolution and for the cure 27% of the cases heal. On the other hand the side effects are more numerous with a good tolerance in the patients under carbamazepine but for the patients under lamotrigine it was noticed that the side effects are lessnumerous and more serious as toxicoderma.