Contrôle De Qualité Et Analyse Physico-Chimiques De Deux Préparations A Usage Antiseptique « Cas De L’alcool Iodée Et De L’eau Oxygenée »

Abstract

The quality control of antiseptic preparations is essential to ensure the safety and effectiveness of products intended to eliminate or inhibit microorganisms on the skin and mucous membranes. It involves a series of physicochemical and microbiological tests designed to verify compliance with regulatory standards and to guarantee optimal antiseptic activity during healthcare procedures. The present study aimed to evaluate the quality and regulatory compliance of two commonly used antiseptics, namely iodinated alcohol and hydrogen peroxide, obtained from different pharmaceutical laboratories. For iodinated alcohol, samples E1, E3, and E4 failed to comply with the density specifications established by the National Formulary (2007). The acidity test indicated that sample E3 was compliant, reflecting satisfactory chemical stability and appropriate preparation and storage conditions. However, all analyzed samples were found to be non-compliant with the iodine assay, exhibiting significantly lower iodine concentrations than required. This deficiency may be attributed to the volatilization of molecular iodine during storage. Regarding hydrogen peroxide, all tested samples complied with Identification Test A, confirming the presence of hydrogen peroxide and indicating that the concentration of reducing substances remained within the limits specified by the pharmacopoeial monograph. In contrast, sample E3 did not meet the requirements of Identification Test B. The acidity test revealed that samples E2, E3, and E5 complied with the established standards, whereas samples E1 and E4 showed non-compliance, likely due to the presence of excessive acidic impurities. The determination of hydrogen peroxide content by manganimetric titration demonstrated that none of the analyzed samples reached the required concentration, indicating non-compliance with quality specifications. This result can be mainly explained by the intrinsic instability of hydrogen peroxide, a compound highly sensitive to environmental factors such as light and heat. In conclusion, quality control of antiseptic preparations constitutes a crucial component of healthcare safety and infection prevention. It ensures that antiseptic products possess adequate antimicrobial activity while maintaining their safety for use on living tissues