Place de la phytothérapie auprès des patientes atteintes du syndrome des ovaires polykystiques

Abstract

In a multidisciplinary approach, this thesis explores the potential of phytotherapy in the management of polycystic ovary syndrome (PCOS), a complex endocrine disorder affecting fertility, metabolism, and hormonal balance in women. The main objective of this work is to highlight the role that certain plant species can play in supporting the disorders associated with PCOS. In this context, an ethnobotanical survey was conducted in the Wilaya of Setif (Algeria) involving 250 patients and 29 herbalists. A botanical study and phytochemical screening were carried out on the three most frequently cited plants from the survey, with the aim of conducting an in-depth study. The results of the two ethnobotanical surveys show that Atriplex halimus is the most commonly used plant, mainly as an infusion. The duration of use of medicinal plants varies widely. Indeed, the survey reveals a generally positive perception of the effectiveness of phytotherapy, with variability in its timing relative to medical treatment for PCOS. Finally, a botanical and phytochemical study of these three species confirmed their identification and revealed a richness in secondary metabolites such as flavonoids, tannins, saponins, mucilages, phytosterols, and alkaloids compounds known for their antioxidant, antiinflammatory, hypoglycemic, and hormone-modulating properties thus indicating their potential therapeutic value in the treatment of PCOS. As such, phytotherapy may represent a complementary approach to PCOS management, provided it is supported by preliminary scientific data and ensures the supervised use of medicinal plants