Etude des gènes HLA de prédisposition chez les enfants cœliaques dans la wilaya de Sétif

Abstract

Celiac disease, whose prevalence in Algeria is high, is an autoimmune disorder by gluten in genetically predisposed individuals carrying HLA-DQ2 or HLA-DQ8 haplotypes. This thesis evaluates, in 120 children with celiac disease followed in Sétif (2018–2021), the frequency of these haplotypes and their clinical correlates. A high HLA positivity rate (80.7%) is reported, consistent with Mediterranean . Female sex shows a significant association with risk haplotypes (adjusted OR ≈ 4.5), while Type 1 Diabetes co-occurs in 17.5% of children, all of whom carry DQ2/DQ8. Supported by its remarkable negative predictive value, HLA typing stands as the first-line tool to rule out celiac disease, refine individual risk stratification, and anchor clinical care within a truly personalized and predictive pediatric medicine framework.