Formulation des comprimés oro-dispersibles exemple : sulpiride 50 mg

Abstract

Our study consisted on the formulation of an orodispersible tablet of sulpiride as well as the evaluation of the impact of certain excipients on the pharmaco-technical properties of the product, in particularly super disintegrants. We used carboxymethyl starch, crosscarmellose and crosprovidone as super-disintegrants in our formulation by adjusting their proportions in the same formula, We found that the time of disintegration of the tablet which is less than 3 minutes was always respected when using all three super-disintegrants in the same formula, However, when removing the disintegrating agents (crosscarmellose and carboxymethyl starch) and keeping the crospovidone in the formula we found a significant impact on the disintegration time that extends beyond the 3 minutes tolerated, this led us to conclude that the property of orodispersibility can only be acquired if crosscarmellose or carobxymethyl starch, which play the role of super disintegrators, are present in our formula.