OPTIMISATION ET FORMULATION D'UNE FORME SEMISOLIDE : CAS D'UN GEL HYDROALCOOLIQUE ENRICHI EN AGENTS PROTECTEURS

Abstract

Introduction : Hand hygiene is one of the most effective measures for preventing healthcare-associated infections. According to the WHO, hydroalcoholic hand sanitizers occupy a prominent position due to their ease of use and broad-spectrum antimicrobial activity. However, repeated use often leads to adverse skin effects, particularly skin irritation, which can result in non-compliance with this hygiene practice. The objective of this study is to optimize and formulate an emollient-enriched hydroalcoholic gel capable of maintaining antiseptic efficacy efficacy while improving skin tolerance. Materials and Methods : Preliminary tests were conducted to select the appropriate concentration of the gelling agent and operating conditions. Various formulations were prepared to study the impact of formulation parameters on the physicochemical, microbiological, stability, and sensory properties of the resulting gels. Results : The prepared formulations exhibited physicochemical characteristics (texture, pH, etc.), stability, and antiseptic activity that meet the required standards. Regarding skin tolerance and hydration studies, a significant improvement in user comfort as well as a reduction in the drying effects typically associated with the use of conventional hydroalcoholic gels was also demonstrated. Conclusion : At the conclusion of this study, the feasibility of an enriched hydroalcoholic gel that combines proven antiseptic efficacy with a significant improvement in user experience, while maintaining control over formulation parameters, constitutes a relevant alternative to conventional formulations