Classical synthesis characterization of an organic- inorganichybrid material, including in silico and experimental studiesof its antioxidant, antibacterial, and anti-inflammatory

Abstract

This work focuses on the synthesis and characterization of newhybridcompounds based on melamine, phosphoric acid, and hydrochloric acid, aimingtoevaluate their biological activities. The study included physico-chemical analyses (solubility, melting point, spectral) as well as biological tests. The results showedthat the compounds possess anti-inflammatory and antioxidant properties, especiallyat low concentrations, while no antibacterial activity was observed against the testedbacteria. Molecular modeling (in silico) supported the hypothesis of effective bindingwith inflammatory receptors. Compound 1/2 demonstrated higher activity than1/1, particularly in terms of anti-inflammatory and antioxidant effects.