L’utilisation de la logique floue dans la pharmacovigilance pour les malades hémodialyses

Abstract

Our work focuses on drug interactions and the intensity of adverse effects caused by them especially in dialysis patients. The objective of our investigation is to determine the intensity of adverse drug reactions in order to prevent them. A survey was carried out by means of a questionnaire of investigation within, the framework of the pharmacovigilance on the intensity of the undesirable effects due to the drug interactions. Intended for the patients of the clinic of dialysis "BOUCENNA" of male and female sex, and of various age groups, in a period of 30 days, by following the method: an assisted, we could collect 40 answers, classified in a summary table. Using artificial intelligence software, we process these results, with 10 inputs (age, gender, geographical area,) and one output (intensity of the adverse effect), each input or output variable is coded as a numerical variable. Once the rule base is established, it becomes possible to instantly read the intensity of the adverse effects of the drug interactions; the result is the collaboration of all the rules that support all the input variables This tool can be considered as an aid to physicians and pharmacists in the prevention of adverse drug interaction events.