Hépatotoxicité médicamenteuse: causes, conséquences et conseils.

Abstract

The liver is the primary organ involved in drug metabolism, which makes it particularly vulnerable to their toxic effects. This toxicity can occur directly, through damage to liver cells (hepatocytes), or indirectly, via immune reactions triggered by the drug. Adverse drug effects on the liver can manifest in various forms, including hepatic cytolysis, cholestasis, hepatic steatosis, vascular disorders, or hypersensitivity hepatitis. Several classes of drugs are known for their hepatotoxic potential, especially when administered at high doses. It is therefore essential to systematically assess the long-term impact of each compound within the framework of pharmacovigilance and to issue precise recommendations regarding its use, in order to prevent potential adverse reactions. This field of research remains highly relevant and offers numerous opportunities for young researchers who wish to contribute to the improvement of drug therapies and the reduction of their hepatic side effects.